NEURO NEWS

A five-year study to assess whether blood tests could help diagnose people with very early Alzheimer's disease is being launched by the NHS. Spotting the condition much sooner would mean people could have more support and new treatments to slow the disease, say experts. 

Currently, there is no single test for Alzheimer's, and patients can wait years for a diagnosis. A blood test would not be able to rule Alzheimer's in or out 100% of the time, but it might be a cheap and easier way to help doctors spot which patients have hidden physical signs of the disease, years before telltale symptoms appear.

There are currently different tests in development around the world, and some are already used in private clinics in the US. They look for traces of brain proteins that have leaked into the bloodstream. These proteins, such as tau and amyloid, start to build up in the brain a decade or more before people develop memory loss and confusion. New Alzheimer's drugs, such as donanemab and lecanemab, can clear some of that brain build-up.

Most amyloid-lowering drug trials so far involve people with advanced disease, and many researchers believe that by the time symptoms set in, the window of opportunity for preventing cognitive decline may have passed already. The drugs might be more effective earlier on in people who have amyloid build-up, but do not have symptoms yet, which is why a blood test could be really useful.

Fiona Carragher, from the Alzheimer's Society, said: "Nearly four in 10 people in the UK who have dementia have not received a diagnosis. We also know that those who do have a diagnosis have often waited many months, sometimes years, to receive it. This means thousands of families are stuck in limbo, trying to manage symptoms and plan for the future without access to the vital care and support that a diagnosis can bring.

"New drugs targeting early-stage Alzheimer's disease are just around the corner, but without a diagnosis, people simply won't be able to access them if they are approved. Having a measurable biomarker for the disease would provide a way to monitor how well new treatments work too.

The NHS Blood Biomarker Challenge has £5m funding from the People's Postcode Lottery.and will look to recruit at least 1,000 NHS patients. The Alzheimer's Society, Alzheimer's Research UK and the National Institute for Health and Care Research are working with the UK Dementia Research Institute at University College London for the project. UK regulators would still need to approve a blood test, and research would need to show it is cost-effective for the NHS to use.

Alzheimer's disease affects about six in every 10 people with dementia in the UK. Alzheimer's is not a normal part of ageing, but the chance of developing the disease increases as we get older.